Retinyl esters form lipid droplets independently of triacylglycerol and seipin

Lipid droplets store neutral lipids, primarily triacylglycerol and steryl esters. Seipin plays a role in lipid droplet biogenesis is thought to determine the site of size newly formed droplets. Here we show seipin-independent pathway biogenesis. In silico vitro experiments reveal that retinyl esters have intrinsic propensity sequester nucleate bilayers. Production mammalian yeast cells do not normally produce causes formation droplets, even strain produces only no other lipids. does or composed These findings indicate seipin depends on type stored forming